This document analyses and specifies the application cases targeting e-Health and publication of Geo-referenced data on the Internet. The goal of this analysis is the identification of a number of demonstration cases that are the main input for the refinement of CLARUS requirements (WP2) and for the CLARUS implementation (WP5). The demonstration cases cover all major aspects of the CLARUS results. The demonstrations developed on the basis of this specification will enable integration testing and support the final evaluation of the project results to be carried out in WP6. In addition, the application cases provide working examples that will support the exploitation and dissemination activities (WP7).